What are Postbiotics?

What is postbiotics?

Postbiotics are natural & functional bioactive compounds comprise of microbial-derived metabolites, ie, SCFAs & proteins that confer health benefits*.

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What are Postbiotics?

Postbiotics over 100 years in Japan

In Japan, postbiotics have been available for over 100 years**, andProfessor Tomotari Mitsuoka*** pioneered in Japan in 1998 to only scientifically develop and study its health effects. (referred in Japan asLactic Acid Bacteria (LAB,aka Probiotics)Metabolitesor Lactobacillus Fermented Extracts)

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What are Postbiotics?

"Naive" question, profound implication

Researchers and biologists over the years have been trying to answer a seemingly"naive"question:why do probiotics have health effects given that probiotics itself just living microbes and NOT nutrients?

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What are Postbiotics?

Postbioitics's direct effect

Postbiotics are now widely recognised asthe primary source of health effect of probiotics^andact on directly on host/human****.

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What are Postbiotics?

Postbioitics: improving absorption disorder for overall health

The recent studies suggest^ that Postbiotics effectively to suppress "bad" bacteria, promote native "good" bacteria growth for restoring gut flora balance and improving absorption disorders, which otherwise induces various diseases includingGI disorders (heartburn, nausea), obesity, constipation, diarrhea, irritable bowel syndrome (IBS), and immune disorders.

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Reference:

  • *Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives. Department of Health Science, Public University of Navarre, 31008 Pamplona, Spain. Foods 2021, 10, 1590.
  • **The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics. Gastroenterology & Hepatology Vol. 18 Sep 2021
  • *** Mitsuoka, T. Intestinal Flora and Probiotics (Gakkai Shuppan Center, 1998)
  • ^Postbiotics and their applications in early life nutrition and beyond. Int J Mol Sci. 2019; 20(19):4673
  • ****The path towards microbiome-based metabolite treatment. Nature Microbiology 2, 17075 (2017)